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Bicalutamide is contra-indicated in females and children and must not be given to any patient who has shown a hypersensitivity reaction to its use.

For the treatment of stage D2 metastatic prostate cancer in combination with a luteinizing hormone-releasing hormone analogue or as a monotherapy. Has been used in clinical trials for ovarian cancer.

In data presented from the largest prostate cancer clinical trial program in the world, Casodex (R) (bicalutamide) 150 mg tablets (manufactured by AstraZeneca) was shown to significantly reduce (42%) the risk of disease progression in men with localized or locally advanced prostate cancer compared to placebo.

AstraZeneca (AZ) has suffered another hard knock after it failed to win regulatory approval from the US food and drug administration (FDA) for the use of high-dose (150mg) Casodex for early stage prostate cancer, The company is already locked in a battle over patent protection for its ulcer drug Losec, which was, the world’s best-selling drug.

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