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Perhaps more than any prescription medication in history, Prozac has had a profound impact, not only on the patients who have taken it, but on the very practice of psychiatry, and on popular conceptions of mood and personality as well. Within three years of its release in 1987, Prozac (fluoxetine hydrochloride) had become the drug most prescribed by psychiatrists in the United States; by 1994 it was the second-best-selling drug of any kind in the world, with a reported one billion prescriptions written per month. In A History of Psychiatry: From the Era of the Asylum to the Age of Prozac, Edward Shorter describes Prozac as the household word of the 1990s; in 1994, Newsweek proclaimed that Prozac had attained the familiarity of Kleenex and the social status of springwater. The drug has been the subject of numerous television programs, magazine articles, and psychology and self-help books. Much more than a medication, Prozac has come to represent the angst and antidote of a generation, as described in Elizabeth Wurtzel's 1994 best-seller, Prozac Nation; and with millions of people taking Prozac each year, and its benefits being touted in the media and discussed at cocktail parties, this new generation antidepressant arguably has contributed to the destigmatization of mental illness.
Released in December 1987 by the Eli Lilly Company, Prozac was the first in a new class of antidepressant medications: the selective serotonin reuptake inhibitors. The SSRIs are “designer drugs,” highly potent chemical compounds that selectively affect a single biological process and, by extension, target a highly specified physiological function. In the case of Prozac (and the other SSRIs, such as Zoloft and Paxil), the target is the brain's reuptake of the neurotransmitter serotonin (5-HT), which is involved in the regulation of mood. By increasing the levels of serotonin available to the brain, Prozac has been found to enhance not only mood, but also energy, assertiveness, and optimism; along with treating anxiety, panic attacks, social discomfort, rejection-sensitivity, and obsessive thoughts. Thus, the effect of Prozac goes beyondProzac without prescription in the us
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