Business Editors/Health & Medical Writers

SAN ANTONIO–(BUSINESS WIRE)–Sept. 23, 2002

In the longest study of a non-hormonal osteoporosis therapy to date, Fosamax(R) (alendronate sodium) continued to help build spinal bone through 10 years of treatment of osteoporosis in postmenopausal women.

The results were presented today at the annual meeting of the American Society for Bone Mineral Research (ASBMR) in San Antonio, Texas.

“Having clinical data on the long-term effectiveness and safety of osteoporosis therapies is very important,” said Henry G. Bone III, M.D., of the Michigan Bone and Mineral Clinic in Detroit. “The results of this study extend our knowledge about treatment of osteoporosis with alendronate over a period of 10 years and were consistent with our earlier findings.”

Fosamax continues to help build spinal bone over 10 years

The study originally began as a three-year trial with 994 osteoporotic, postmenopausal women between the ages of 45 and 82. The multi-center, double-blind, randomized, placebo-controlled study was extended, so that patients were studied over 10 consecutive years of treatment. Patients originally were randomized into four groups, receiving 5 mg, 10 mg or 20 mg of Fosamax, or placebo. The groups taking Fosamax 5 mg and 10 mg remained on these doses for the entire 10 years.

The study showed that treatment with daily oral alendronate 10 mg for 10 years in 86 patients resulted in:

— one 70 mg tablet once weekly or — one 10 mg tablet once daily

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The safety and tolerability profile of Fosamax was similar to that seen in other studies with Fosamax 5 mg and 10 mg.

About osteoporosis

Menopause is a key factor contributing to the development of osteoporosis, caused when there is an imbalance in bone-building cycles and more bone is broken down than is replaced.(1) This can lead to osteoporosis, a silent disease that causes bones to become more porous, gradually making them weaker, more brittle and prone to fracture.

“Physicians have been concerned about the long-term effects of bisphosphonates like risedronate and alendronate. This study is the first to show that alendronate was generally well-tolerated over a 10-year period of time, while at the same time it helped to provide continuous increases in bone mass,” said Ronald Emkey, M.D., medical director, Radiant Research in Reading, PA.

Important information about Fosamax

Fosamax, like other bisphosphonates, should be used with caution in people with certain stomach or digestive problems. Fosamax should not be used if the patient has certain disorders of the esophagus that delay emptying or if the patient is unable to stand or sit upright for at least 30 minutes. In addition, Fosamax should not be used in patients with severe kidney disease or low levels of calcium in their blood, in patients who are allergic to Fosamax or in patients who are pregnant or nursing.

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Thirty Utah residents on Thursday joined the some 4,000 people nationwide who have sued the makers of Paxil, a popular anti- depressant from the British drug company GlaxoSmithKline.

According to a lawsuit filed in U.S. District Court, the Utahns all suffered severe reactions after attempting to stop taking Paxil, which allegedly had been marketed as non-habit-forming.

“At all times relevant herein, (GlaxoSmithKline) knew that Paxil could cause severe withdrawal reactions but for years concealed, suppressed and downplayed the severity and frequency of their existence to plaintiffs, the medical community and the consuming public,” the suit states. “As a result, plaintiffs were deprived of their ability to exercise their full and informed consent when deciding to take Paxil.”

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Accutane is a heavy-duty drug. It should only be used as a last resort, after you’ve exhausted all other possible options. Before I was able to find a permanent cure for my acne, I was on Accutane for an extended period of time. Not only were the side effects awful, it also didn’t work to totally clear up my acne. If you’re thinking about starting Accutane treatment, consider the following consequences before going through with it.

The most serious side effects:

Accutane can cause devastating birth defects, which include mental retardation and physical deformation. You cannot take Accutane if you’re pregnant, and if you become pregnant while on the drug, you must consult a doctor immediately.

They’re not joking around about this. When I got my packages, each and every pill had an anti-pregnancy symbol emblazoned on it. The birth defects caused by Accutane are incredibly severe.

In addition, because of how Accutane is processed by the liver, you cannot drink any alcohol during treatment due to a risk of liver failure. You need to have blood drawn once a month while on the drug to ensure that your liver toxicity is at a normal level.

What I experienced:

When I was on Accutane, I felt like all the moisture had been sucked right out of my body. My skin cracked and split all over, my lips bled, my eyes dried up so much I couldn’t (and still can’t) wear contact lenses, and I suffered from regular nosebleeds. Not a pleasant experience, to say the least.

What you might experience in addition to the above:

I was fortunate enough to avoid the following side effects, but you should be warned about them nonetheless. Accutane may also cause you to experience chest pain, decreased night vision, constant fatigue, thinning hair, vomiting, bowel inflammation… And the list goes on.

There have also been claims that Accutane causes serious depression, but no such claim has been medically proven. I myself didn’t suffer from depression when I was taking the drug; I was just disappointed that it didn’t work out.

Despite all of the risks, Accutane does have the potential to work miracles on some people. Unfortunately, I wasn’t one of them. In the end, however, I was able to find an acne medication that cleared up my skin perfectly, without the awful side effects I experienced when I was on Accutane.

If you’re thinking about getting a prescription for Accutane, I urge you to consider all of the risks and the side effects associated with treatment.

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Perhaps more than any prescription medication in history, Prozac has had a profound impact, not only on the patients who have taken it, but on the very practice of psychiatry, and on popular conceptions of mood and personality as well. Within three years of its release in 1987, Prozac (fluoxetine hydrochloride) had become the drug most prescribed by psychiatrists in the United States; by 1994 it was the second-best-selling drug of any kind in the world, with a reported one billion prescriptions written per month. In A History of Psychiatry: From the Era of the Asylum to the Age of Prozac, Edward Shorter describes Prozac as the household word of the 1990s; in 1994, Newsweek proclaimed that Prozac had attained the familiarity of Kleenex and the social status of springwater. The drug has been the subject of numerous television programs, magazine articles, and psychology and self-help books. Much more than a medication, Prozac has come to represent the angst and antidote of a generation, as described in Elizabeth Wurtzel's 1994 best-seller, Prozac Nation; and with millions of people taking Prozac each year, and its benefits being touted in the media and discussed at cocktail parties, this new generation antidepressant arguably has contributed to the destigmatization of mental illness.

Released in December 1987 by the Eli Lilly Company, Prozac was the first in a new class of antidepressant medications: the selective serotonin reuptake inhibitors. The SSRIs are “designer drugs,” highly potent chemical compounds that selectively affect a single biological process and, by extension, target a highly specified physiological function. In the case of Prozac (and the other SSRIs, such as Zoloft and Paxil), the target is the brain's reuptake of the neurotransmitter serotonin (5-HT), which is involved in the regulation of mood. By increasing the levels of serotonin available to the brain, Prozac has been found to enhance not only mood, but also energy, assertiveness, and optimism; along with treating anxiety, panic attacks, social discomfort, rejection-sensitivity, and obsessive thoughts. Thus, the effect of Prozac goes beyondProzac without prescription in the us
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WASHINGTON — The Food and Drug Administration has approved the switch of Claritin, the top-selling prescription allergy medication manufactured by Schering-Plough Corp., to over-the-counter status effective this month. The switch should result in substantial savings for the uninsured, while probably costing the insured more money.

West, Diane

EAST HANOVER, N.J. — Novartis announced recently that it plans to market a generic version of Schering-Plough Corp.’s popular allergy medicine Claritin. A Novartis spokesman says the generic allergy remedy will be manufactured by the generic drug maker IMPAX Laboratories Inc. and will be marketed through Novartis’ Consumer Health division.

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Cialis is finding an increasing number of takers because of its great ability to treat erectile dysfunction and stimulate sex drive. If you are in the market to purchase Cialis then you should take them exactly as how your doctor prescribes. Cialis is a prescription drug that is orally taken for treating erectile dysfunction. Doctors usually recommend a dose of 10 mg of Cialis to start with. This libido booster is not to be taken more than once in a day. You can always shop for Cialis once you consult your doctor. Cialis is known to cause sudden drop in blood pressure if taken along with other medicines. These medicines include alpha-blockers and nitrates or certain other recreational drugs which contain nitrates, popularly referred to as

AstraZeneca has presented the results of a clinical trial in its GALAXY program of Crestor (rosuvastatin) at the the American College of Cardiology meeting, as it continues its marketing offensive to set the stage for the international roll-out of the drug, which debuted in its first markets earlier this year (Marketletters passim).

AstraZeneca, Wilmington, DE, is aggressively disputing charges by a US Food and Drug Administration (FDA) official and a public health watchdog group that the cholesterol-lowering drug is linked to high rates of kidney failure.

In testimony before the Senate Finance Committee, FDA safety reviewer David Graham included Crestor in a list of 5 drugs approved by FDA that may pose health dangers to the public. Public Citizen, a nonprofit consumer advocacy organization, was already on record charging that the rate of kidney failure or damage among patients taking Crestor is 75 times higher than all patients taking other statins.

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Mylan Laboratories Inc. has received approval from the Food and Drug Administration to market buspirone hydrochloride tablets 15 mg., the generic equivalent to Bristol-Myers …

The duration of treatment is not limited, but the prescribing physician should reassess in regular intervals, if continued treatment is still necessary.

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Spring Valley, N.Y.-based Pharmaceutical Resources has received FDA approval to market buspirone hydrocholride in 7.5 mg tablet form. Beginning March 29, Par has 180 days of marketing exclusivity for this dosage. Buspirone is the generic equivalent of Bristol-Myers Squibb’s anxiety drug BuSpar.

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For many years now men have been boasting about the effects that Viagra has on their sex drive and certainly sales of this product do not seem to be dwindling. But today not only are their products available for men to increase their sex drive now women have the chance to do the same using Female Viagra products such as creams or supplements.

One of the more well known of the libido enhancement products that you will see being advertised on the internet today is Vigorelle. This cream acts very fast and only simply needs to be applied to clitoral area on a woman just before she is about to have sex.

This product is made using only natural ingredients and does not act as a lubricant. What it in fact does once the cream has been applied to the clitoral region is that it helps to release the vagina’s natural juices and this then increases the size and sensitivity of this part of a woman’s body. Vigorelle has been produced using Western herbalist and Traditional Chinese medicine methods. Although there are other such creams available on the market today Vigorelle is one of the few that is made using only natural organic botanical ingredients. This means that they contain no preservatives, perfume or unnatural ingredients which could cause side effects.

These ingredients are made up in a certain formulation in order to help improve the woman’s sensations during sex. Not only does is stimulate the woman’s sexual response but it also boosts her arousal levels as well as increasing lubrication to the genital area.

The product needs to be directly applied to the clitoris in order for it to deliver the maximum effect to a woman in relation to her sexual fulfillment. The effects of this cream are activated through a woman touching it. In fact the best way of achieving the best results possible when using this particular type of female Viagra is by applying several drops to the underside of your clitoral membrane and then massage it in using small circular motions.

So if you are looking for a way to improve your sex life with your partner and help to increase your libido then you should seriously consider thinking about using a female Viagra cream such as Vigorelle.

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Diabetes is a strange disease. To this day, we really don’t know what causes it and we can’t recreate it in a laboratory setting. However, we do have treatments for diabetes. One of those treatments is Actos. This article is going to explain what Actos is, how it works and what the potential risks of this drug are. Hopefully, after reading this, you will be able to make an informed decision as to whether or not Actos is something you want to take.

Actos is actually the brand name for the drug pioglitazone. It comes in tablet form in strengths of 15, 30 and 45 milligrams. The drug is manufactured by Takeda Chemical Industries, Ltd. It is available by prescription only and was approved by the FDA on July 15, 1999. Of course FDA approval means very little these days. If you doubt that, just take a look at the Voixx debacle.

The thing that diabetics need to know about Actos is that it is for type 2 diabetes only. This drug will not work for type 1, or juvenile diabetes or diabetic ketoacidosis. Also, if you suffer from heart failure, have fluid retention or any kind of liver disease, Actos may not be an option for you. You’ll need to check with your doctor and he will make an evaluation.

What Actos does is it improves blood sugar control in patients with type 2 diabetes. Actos can be used with a variety of other drugs in combination with diet and exercise when Actos alone is not sufficient enough to keep the patient’s sugar level under control.

The biggest risk from taking Actos is liver damage. In extreme cases use of this drug can lead to the liver transplant or death. Before prescribing Actos for you, your doctor will do tests on your liver to determine if it is safe for you to take the drug. Of course this is only a guess. All drug use comes with risks.

Another danger of taking Actos is that your blood sugar may actually get too low.This actually occurs when taking Actos with insulin. If you suspect you are suffering from low blood sugar, which is usually characterized by light headedness and fainting, call your doctor immediately.

If you’re a woman taking Actos who has reached menopause, there is the possibility that Actos can start you ovulating again. If this happens and you engage in unprotected sex, you could get pregnant. Please keep this in mind.

Some of the more common side effects from taking Actos are coughs, headaches, colds, stuffy nose, sore throat, muscle pain, swelling and water retention.

They say sometimes the cure is worse than what ails us. Actos has the potential to be life threatening. If you’re interested in natural treatments for diabetes, they are out there. You’ll find more information in my signature.

To YOUR Health,

Steve Wagner

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